Who We Are
Shuaiying Cui, Ph.D. Assistant Professor of Medicine Principal Investigator
Yanan Sun, Ph.D. Postdoctoral Fellow
Kate Gaynor, Undergraduate Student
Anita Dong, Undergraduate Student
Nika Kozlov, Undergraduate Student
Nicole Nguyen, Undergraduate Student
Jhevanae Langley, Undergraduate Student
Raymon Chen, Undergraduate Student
What We Do
Our research has focused on the development of novel agents that can elicit developmental stage-specific gene silencing or reprogramming in hematopoietic stem cells and progenitors through a series of epigenetic chromatin modifications by nucleosome remodeling, histone deacetylation, and demethylation. Such agents can be applied to the treatment of the patients with hematologic disorders such as sickle cell disease and beta-thalassemia, as well as acute myeloid leukemia (Blood cancer), which arise from congenital defects in the genome. The findings from these preclinical studies could also help to establish therapeutic indications in other hematological malignancies, and help to understand the basic mechanisms of hematologic development, function, and disease.